Publicaciones

Cariprazine as a maintenance treatment in dual schizophrenia: a 6-month observational study in patients with schizophrenia and cannabis use disorder

Nestor Szerman, Pablo Vega, Carlos Roncero, Lola Peris, Lara Grau-López, Ignacio Basurte-Villamor

Schizophrenia is often associated with substance use disorders, particularly cannabis use disorder (CUD). However, treatments frequently fail to address both conditions simultaneously. This study aimed to evaluate the antipsychotic effectiveness of cariprazine in patients with both schizophrenia and CUD in a real-world setting. A 6-month observational study was conducted on 58 patients diagnosed with schizophrenia and CUD, treated with cariprazine. Antipsychotic effectiveness was measured using the Positive and Negative Syndrome Scale and the Clinical Global Impression-Schizophrenia Scale, along with the Improvement and Severity scales. Cannabis consumption and addiction severity were assessed using the Cannabis Abuse Screening Test and the Severity of Dependence Scale, while functioning was evaluated with the Sheehan Disability Inventory. Cariprazine treatment resulted in significant improvements in schizophrenia symptoms (Positive and Negative Syndrome Scale change: -47.88 points, P < 0.0001; Clinical Global Impression-Schizophrenia Scale change: -8.26 points, P < 0.0001). Cannabis use and dependence also decreased (Cannabis Abuse Screening Test change: -7.0 points, P < 0.0001; Severity of Dependence Scale change: -7.88 points, P < 0.0001), alongside improvements in functioning (Sheehan Disability Inventory change: -9.48 points, P < 0.0001). These results suggest that cariprazine is effective for both schizophrenia and CUD, though further research is needed to confirm these findings.

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

¿Existe el Trastorno por juego de Apuestas Dual?

Con este título se ha publicado, por parte de un grupo de investigación de Madrid, un artículo descriptivo, transversal y observacional, sobre personas diagnosticadas de Trastorno por Juego de Apuestas.

Esta investigación ha sido financiada fundamentalmente por La Fundación Patología Dual (SEPD)

Tobacco use disorder in patients with other mental disorders: a dual disorder perspective from clinical neuroscience. 11 October 2024. Publicado en Frontier in Psychiatry

Tobacco use disorder and other mental disorders: The neglected dual disorder. Publicado en Spanish Journal of Psychiatry and Mental Health. 11 Mayo 2024

Posicionamiento de la Sociedad Española de Psiquiatría y Salud Mental y la Sociedad Española de Patología Dual, en forma de suplemento: TRASTORNO POR USO DE TABACO Y PATOLOGÍA DUAL

Gambling Dual Disorder: A Dual Disorder and Clinical Neuroscience Perspective

Results of a Hepatitis C Micro-Elimination Program in Two Addiction Centers Among Subjects With Substance Use Disorder

A Feasibility Study of Patients with Major Depression and Substance Use Disorders: Vortioxetine as Maintenance Treatment